Epigenetics is the study of how environmental and behavioral factors can impact how genes function without changing the DNA sequence. New scientific research shows that environmental influences can actually affect whether and how genes are expressed. In fact, scientists have discovered that early experiences can determine how genes are turned on and off and even whether some are expressed at all. By analogy, might it be possible that how an organization defines and actually embodies its own culture’s values– evolutionary 21st century values–will strongly influence its outcomes not only in this but also future generations? And because of the consequence of private organizations, for profit, non-profit, and Fourth Sector on millions of lives around the world, do we not in a modest way have a chance to reshape our collective destinies by applying the principles and practices of Kokoro?